منابع مشابه
Peripheral B Lymphocytes
Background: Based on the hypothesis that IgGs are potent tolerogens and that immature lymphohematopoietic antigen-presenting cells (APC), and even mature peripheral B cells, may be effective APC for tolerance induction, we designed an immunoglobulin fusion protein retroviral expression vector to test the role of B cells in a novel gene therapy strategy for the transfer of immune tolerance. Meth...
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Many bursa-equivalent (B) lymphocytes of adult mice bear surface Ig and receptors for C3. The frequency of Ig-bearing cells increases rapidly immediately after birth, but these cells lack complement (C) receptors. Lymphocytes bearing C receptors are not found in the spleens of BALB/c, DBA/2, and C57BL/6 mice until 2 wk of age and do not attain substantial numbers until 3-4 wk of age. In AKR mic...
متن کاملTranscriptional stalling in B-lymphocytes
B cells utilize three DNA alteration strategies-V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)-to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of these three events, the single-strand DNA cytidine deaminase, Activation Induced cytidine Deaminas...
متن کاملPrecursors of Murine B Lymphocytes
The precursors of B lymphocytes have previously been distinguished and characterized by various parameters including their ability to generate B cells after adoptive transfer, expression of surface markers a n d / o r B cell function after short-term induction in vitro, and their synthesis but not surface display o f immunoglobu l in (Ig) heavy chains (1-19). The extent to which these cells are...
متن کاملChromosome Aberrations in B Lymphocytes
Although chromosome aberrations in T lymphocytes and bone marrow cells have been reported in atomic bomb survivors, the presence of chromosome abnormalities has not been demonstrated in B lymphocytes because of the technical difficulties involved in B-lymphocyte separation. A method for detecting chromosome aberrations in B lymphocytes was established by “stimulation” of B lymphocytes with Epst...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2014
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/20143010014